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Bone Healing

Bone healing is the sequence of biological stages the body moves through after a fracture or bone surgery: an inflammatory phase at the injury site, a soft callus of cartilage and collagen, a hard callus as minerals are deposited into that scaffold, and a remodeling phase in which the new bone is gradually reshaped. These are processes the body carries out itself. How long each stage takes varies from person to person, and it is a clinician who assesses where a patient is in the process, using examination and imaging rather than a fixed schedule. When healing does not progress as expected, clinicians use the terms delayed union and nonunion. Nutrition is one of several areas a clinician may review during recovery, because nutrients including protein, calcium, magnesium, vitamin D, vitamin K, and zinc are involved in normal bone biology and bone metabolism. This page is educational and is not medical advice; questions about a specific injury or recovery belong with a qualified healthcare provider.

Bone Healing

How Medical Foods Can Help

Iaomai's bone formulas, EB-S4 and EB-S5, are medical foods for the dietary management of the metabolic processes associated with bone healing, and they are intended to be used under the supervision of a physician. They supply nutrients with recognized roles in skeletal biology. EB-S4 provides calcium as calcium citrate, the principal mineral of the bone matrix; magnesium as bisglycinate, a mineral involved in bone metabolism; cholecalciferol (vitamin D3), which the body uses in intestinal calcium absorption; and zinc, a cofactor for enzymes involved in protein synthesis and bone tissue formation. EB-S5 provides calcium, magnesium as glycinate, vitamin D3, and vitamin K2 as MK-7, a cofactor for the carboxylation of osteocalcin and other bone matrix proteins. The formulas do not act on a fracture or on bone disease. They are a way to supply these nutrients in defined, measured amounts while your physician directs and monitors your overall care.

Minerals of the Bone Matrix

Calcium is the principal mineral deposited in bone, and magnesium is involved in bone metabolism and in the enzyme systems that handle calcium. EB-S4 supplies calcium as calcium citrate together with magnesium bisglycinate, and EB-S5 supplies calcium together with magnesium glycinate.

Vitamin D3 and Vitamin K2 in Bone Biology

Cholecalciferol (vitamin D3), included in both formulas, plays a role in intestinal calcium absorption. Vitamin K2 as MK-7, included in EB-S5, is a cofactor for the carboxylation of osteocalcin, one of the proteins of the bone matrix.

Zinc's Role in Bone Tissue

Zinc is a cofactor for enzymes involved in protein synthesis and in the formation of bone tissue. It is included in EB-S4 alongside the mineral and vitamin components of the formula.

Common Symptoms

  • Delayed fracture healing
  • Poor bone density
  • Slow post-operative recovery
  • Increased fracture risk
  • Compromised bone quality

What Causes Bone Healing?

Clinical descriptions of bone healing point to several contributing factors: an adequate blood supply to the injury site, mechanical stability from immobilization or fixation, and the availability of the nutrients the body uses to build bone matrix. Delayed union and nonunion are associated with disruption to any of these. Poor vascular supply, movement at the fracture site, and infection are recognized contributors, as are metabolic conditions such as diabetes and osteoporosis, which are associated with changes in bone quality and in the remodeling process. Remodeling capacity is also recognized to change with age. Smoking is associated with reduced blood flow to healing tissue, and heavy alcohol use is associated with disrupted bone formation. Nutritional status is part of the clinical picture as well, and several nutrients have recognized roles in bone biology: protein is a component of the collagen scaffold, calcium is the principal mineral of the bone matrix, magnesium is involved in bone metabolism, vitamin D plays a role in intestinal calcium absorption, vitamin K is involved in the carboxylation of osteocalcin, and zinc acts as a cofactor for enzymes involved in protein synthesis and in the formation of bone tissue. Inadequate intake or deficiency of these nutrients is one of the things a clinician may consider when assessing a patient's overall nutritional status. None of this describes a product or promises an outcome: nutrition is one factor among several, and decisions about care belong with the treating clinician.

Medical Foods for Bone Healing

Our scientifically-formulated medical foods are designed to address the nutritional needs specific to Bone Healing.

EB-S4

Bone Healing

EB-S4

Calcium, magnesium bisglycinate, cholecalciferol, and zinc for bone health support.

EB-S5

Bone Healing

EB-S5

Delayed release bone healing formula with calcium, magnesium glycinate, and vitamin K2.

Dr. Hecker recommended a genetic test, which revealed a mutation in a gene. After a year on a supplement, my almost constant shin pain is nearly completely gone. I am back to running normally. Amazing knowledge of such a unique field of study.
Kirstin K. · MTHFR Testing

Individual experience. Results vary from person to person and are not typical or guaranteed. Testimonials describe one person's experience and are not evidence that any product will work for you. Iaomai Health products are medical foods for the dietary management of specific conditions, intended for use under the supervision of a physician.

Struggling with Bone Healing?

Our healthcare professionals can help you decide whether a medical food fits the dietary management of your condition, as part of a care plan they supervise.

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Frequently Asked Questions

Get answers to common questions about Bone Healing and our medical food approach.

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